In recent years Karo Bio has built up resources for preclinical development to enable selection of high quality drug candidates. In house resources include animal models for ADME (absorption, distribution, metabolism and excretion) as well as resources for pharmacokinetics, bioanalysis and in vivo pharmacology. In-house competences for safety pharmacology and toxicology are also available. In addition to these resources Karo Bio utilize contract organizations to characterize compounds. When a compound fulfills preset criteria for efficacy and safety in these models a candidate drug is selected. A documentation package for regulatory approval, before starting clinical trials, is prepared after additional external toxicology studies.