Drug discovery at Karo Bio starts with target validation which means that a specific nuclear receptor is mechanistically linked to a disease. The target validation process is guided by Karo Bio's unique competence in the field of nuclear receptor structure and function and is conducted in close collaboration with clinical experts. The search for a molecule that binds to the receptor and modulates the function of the receptor is very much driven by structural biology and medicinal chemistry. In this process, Karo Bio determines the three-dimensional structures of receptors and designs molecules that bind to the receptors in a way which modifies the disease process. Our leading position in nuclear receptor structure biology has enabled the design of innovative molecules and unique compound libraries.